Can You Take 800 Mg Ibuprofen With 50 Mg Tramadol

Mar 31, 2019

Klauy asked

I was just wondering if I tin take 600 mg ibuprofen and tramadol fifty mg in i 24-hour interval for pain.

At a glance

• Tramadol and ibuprofen can safely be taken the aforementioned solar day as there is no known drug interaction betwixt them. Be sure to only use them every bit directed by your doctor however.

Respond

Yes, for most individuals, it is safe to take tramadol and ibuprofen the same twenty-four hour period. There is no known interaction betwixt the two medications.^[1]

While they are both used for pain, they are in different medication classes.

Ibuprofen is an NSAID (non-steroidal anti-inflammatory drug) while tramadol is an opioid agonist (and too has a weak outcome on norepinephrine and serotonin).

Since they have unlike mechanisms of action, they can have synergistic effects and some studies have fifty-fifty used both (or like drugs) in combination for the handling of moderate to astringent pain/inflammation.^[2]

One common method for using tramadol and ibuprofen together is to apply ibuprofen for mild pain/inflammation and reserve tramadol for any breakthrough pain symptoms.^[three]

Tramadol may provide more effective hurting relief for some individuals but is by and large reserved for use since it is an opioid (like codeine), a controlled substance and has a risk of dependence and abuse.

Side Outcome Concerns

Using both together shouldn't significantly increment your risk of side effects just they are both known to cause gastrointestinal problems, including:

• Nausea
• Diarrhea
• Constipation
• Abdominal hurting
• Stomach cramping

Since tramadol can affect serotonin, at that place was some concern that it could thin the blood, especially when used in combination with other drugs that thin the blood (similar ibuprofen). Almost studies, however, study that tramadol is non associated with an increased risk of bleeding.^[four]

Lastly, it is important to note that tramadol is non known to take anti-inflammatory properties then if what yous are treating involves inflammation, ibuprofen volition probable exist more than constructive in reducing it.^[five]

References

1. ^ Elsevier ClinicalKey Drug-Drug Interactions. ClinicalKey (Subscription Required)
2. ^ Pain Handling in Arthritis-Related Hurting: Beyond NSAIDs PubMed
3. ^ Tramadol Prescribing Information
4. ^ Risk of upper gastrointestinal haemorrhage associated with non-aspirin cardiovascular drugs, analgesics and nonsteroidal anti-inflammatory drugs. PubMed
5. ^ Low-Dose Tramadol and Non-Steroidal Anti-Inflammatory Drug Combination Therapy Prevents the Transition to Chronic Low Dorsum Hurting. PubMed

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